CT-guided bone cement injection combined with artificial tiger bone meal to repair osteoporotic vertebral compression fractures: callus growth and bone healing

doi:10.3969/j.issn.2095-4344.2015.03.002

Abstract

Abstract:

BACKGROUND: Minimally invasive surgery for osteoporotic vertebral compression fractures obtained apparent effects. This method can support the vertebral height recovered and hardness, relieve the pain, and achieve early activity. However, long-term bed rest after surgery will induce many complications, and the prognosis will be not ideal. At present, many Chinese herbs have been used to restore osteoporotic vertebral compression fractures.

OBJECTIVE: To observe callus formation and fracture healing in patients with osteoporotic vertebral compression fractures repaired by CT-guided minimally invasive surgery with bone cement injection and artificial tiger bone meal.

METHODS: A total of 85 cases of osteoporotic vertebral compression fractures were selected. Patients were randomly divided into observation group (n=43) and control group (n=42). Patients in the observation and control groups respectively received CT-guided minimally invasive percutaneous vertebroplasty, matching with artificial tiger bone meal and Jiegu Qili pill. Callus growth, fracture healing and pain relief time were observed in the two groups.

RESULTS AND CONCLUSION: The callus growth was good in patients of the observation group, mainly grade III and IV, and significantly better than in the control group (P < 0.05). Pain relief time and healing time were significantly shorter in the observation group than in the control group (P < 0.05). The excellent and good rate of Japanese Orthopaedic Association score was significantly better in the observation group than in the control group (P < 0.05). These results suggested that CT-guided minimally invasive percutaneous vertebroplasty in the combination with bone cement injection for osteoporotic vertebral compression fractures can obtain evident effects. The combined use of artificial tiger bone meal has a good promoting effect on fracture healing.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: Spinal Fractures, Osteoporotic Fractures, Fractures, Compression, Bony Callus, Fracture Healing

CLC Number:

R318

Min Peng, Zhang Yan-ping, Cao Hong. CT-guided bone cement injection combined with artificial tiger bone meal to repair osteoporotic vertebral compression fractures: callus growth and bone healing[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(3): 335-339.

Figures/Tables 5

References

[1]吕小华,陈科.金天格胶囊治疗骨质疏松症200例[J].现代中西医结合杂志,2009,18(7):788-789.
[2]王晋平,张佳红,王慧娟,等.金天格胶囊治疗骨关节炎临床疗效分析[J].中国医院药学杂志,2011,31(10):848-850.
[3]赵冀伟.金天格胶囊治疗骨质疏松性骨折50例临床研究[J].中国骨质疏松杂志,2012,18(1):63-65.
[4]姜波,闻辉,杨春辉.金天格胶囊治疗原发性骨质疏松症的临床疗效[J].中国社区医师(医学专业),2010,12(35):123.
[5]杨宇君,武晓波,向川.金天格胶囊治疗骨质疏松症的临床研究[J].中国医疗前沿(上半月),2011,6(9):32-33.
[6]Kim KW,Ha KY,Moon MS.Volumetric change of the grit bone after intertransverse fusion.Spine. 1999;8(4):221.
[7]Lied B,Roenning PA,Sundseth J.Anterior cervical discectomy with fusion in patients with cervical disc degeneration:a prospective outcome study of 258 patients (181 fused with autologous bone graft and 77 fused with a PEEK cage).BMC Surg. 2010;8(4):554.
[8]Fraser JF,Hartl R.Anterior approaches to fusion of the cervical spine:a metaanalysis of fusion rates. J Neurosurg Spine. 2007;5(2):189.
[9]Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004; 328(7454): 1490.
[10]Zhang B, Dai M, Tang Y. Unilateral versus bilateral kyphoplasty for osteoporotic vertebral compression fractures. Adv Mat Res. 2012; 393:1064-1068.
[11]Luo XL, Zheng CK, Kan WS, et al. Unilateral versus bilateral percutaneous kyphoplasty for the treatment of osteoporotic compression fractures. Chin J Tissue Eng Res. 2012; 16(3): 567-570.
[12]Pignatello R, Cenni E, Micieli D, et al. A novel biomaterial for osteotropic drug nanocarriers: synthesis and biocompatibility evaluation of a PLGA-ALE conjugate. Nanomedicine 2009; 4: 161-175.
[13]Ma YL, Dai RC, Sheng ZF, et al. Quantitative association between osteocyte density and biomechanics, microcrack and microstructure in OVX rats vertebral trabeculae. J Biomech. 2008; 41:1324-1332.
[14]Teo JC, Si-Hoe KM, Keh JE, et al. Correlation of cancellou bone microarchitectural parameter from microCT to CT number and bone mechanical properties. Mater Sci Eng C. 2007; 27:333-339.
[15]Boyd SK, Davision P, Muller R, et al. Monitoring individual morphological changes overtime in ovariectomized rats by in vivo micro-computed tomography. Bone. 2006;39: 854-862.
[16]Waarsing JH, Day JS, van der Linden JC, et al. Detecting and tracking local changes in the tibiae of individual rats: a novel method to analyse longitudinal in vivo micro-CT data. Bone. 2004; 34:163-169.
[17]Sheng Z, Dai R, Wu X, et al. Regionally-specific compensation for bone loss in the tibial trabeculae of estrogen deficient rats. Acta Radiologica. 2007; 48: 531-539.
[18]Zhang SD, Wang C, Jiang XJ, et al. Experimental research on biomechanics of calcium sulfate cement in thoracolumbar burst fractures. Ortho J Chin. 2009;17:1-5.
[19]Yun MH, Kwon KI. High-performance liquid chromatography method for determining alendronate sodium in human plasma by detecting fluorescence: Application to a pharmacokinetics study in humans. J Pharm Biomed Anal. 2006;40:168-172.
[20]Rhim SY, Park JH, Park YS, et al. Bioavailability and bioequivalence of two oral formulations of alendronate sodium 70 mg: an open-label, randomized, two-period crossover comparision in healthy Korean adult male volunteers. Clin Ther. 2009; 31:1037-1045.
[21]Keaveny TM, Hayes WC. A 20-year perspective on the mechanical properties of trabecular bone. J Biomech Eng. 1993; 115:534-542.